群馬県立県民健康科学大学 > トピックス > 診療放射線学部教員の論文が国際誌に掲載されました。
診療放射線学部教員の論文が国際誌に掲載されました。

診療放射線学部 原孝光教授の原著論文が国際学術誌に掲載されました。

論文タイトル:Metastasis of breast cancer cells to the bone, lung, and lymph nodes promotes resistance to ionizing radiation.

著者:Takamitsu Hara1, Manabu Iwadate2, Kazunoshin Tachibana3, Satoshi Waguri4, Seiichi Takenoshita5, Nobuyuki Hamada6

1 Department of Radiological Technology, School of Radiological Technology, Gunma Prefectural College of Health Sciences.
2 Department of Thyroid and Endocrinology, School of Medicine, Fukushima Medical University.
3 Department of Breast Surgery, School of Medicine, Fukushima Medical University.
4 Department of Anatomy and Histology, School of Medicine, Fukushima Medical University.
5 Advanced Clinical Research Center, Fukushima Global Medical Science Center, School of Medicine, Fukushima Medical University.
6 Radiation Safety Research Center, Nuclear Technology Research Laboratory, Central Research Institute of Electric Power Industry (CRIEPI).

掲載雑誌:Strahlentherapie und Onkologie, Journal of Radiation Oncology, Biology, Physics 2017 Jun 22.

https://link.springer.com/article/10.1007%2Fs00066-017-1165-2

要旨: 乳癌は最も転移しやすい腫瘍の一つであり、その対策が急務である。放射線治療は、原発乳癌だけではなく、転移乳癌に対しても実施されているが、その放射線応答性の違いは必ずしも明らかではない。そこで乳癌の原発腫瘍細胞と転移腫瘍細胞の特徴を詳細に調べる事の出来る動物モデルは非常に有用である。我々はそのモデルの開発に成功し、実際に転移細胞は、原発細胞に比べて、増殖能、浸潤能などが亢進し、放射線抵抗性を示すことを確認した。この研究は、乳癌転移の放射線治療を行う場合、その投与線量の最適化に大きく貢献すると考える。

Abstract
BACKGROUND:
Metastasis represents the leading cause of breast cancer deaths, necessitating strategies for its treatment. Although radiotherapy is employed for both primary and metastatic breast cancers, the difference in their ionizing radiation response remains incompletely understood. This study is the first to compare the radioresponse of a breast cancer cell line with its metastatic variants and report that such metastatic variants are more radioresistant.
MATERIALS AND METHODS:
A luciferase expressing cell line was established from human basal-like breast adenocarcinoma MDA-MB-231 and underwent in vivo selections, whereby a cycle of inoculations into the left cardiac ventricle or the mammary fat pad of athymic nude mice, isolation of metastases to the bone, lung and lymph nodes visualized with bioluminescence imaging, and expansion of obtained cells was repeated twice or three times. The established metastatic cell lines were assessed for cell proliferation, wound healing, invasion, clonogenic survival, and apoptosis.
RESULTS:
The established metastatic cell lines possessed an increased proliferative potential in vivo and were more chemotactic, invasive, and resistant to X‑ray-induced clonogenic inactivation and apoptosis in vitro.
CONCLUSION:
Breast cancer metastasis to the bone, lung, and lymph nodes promotes radioresistance.

 

2017年07月31日

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