原孝光｜群馬県立県民健康科学大学

Home > 群馬県立県民健康科学大学：教員紹介 > 診療放射線学部 > 診療放射線学科 > 原孝光

原孝光

HARA Takamitsu

所属

大学院診療放射線学研究科 / 診療放射線学部放射線学科

職名

教授

専門分野

放射線生物学、医学物理学

研究課題

急性放射線障害に対するヒト胎盤由来間葉細胞治療の非臨床有効性検証研究
大腸癌に対するEGFR経路の抑制を基盤とした新たな分子標的放射線療法の開発
ヒト乳癌細胞の転移能と放射線感受性に関する研究

主な論文・著書

[原著　英文]

Ishii S, Hara T, Nanbu T, Suenaga H, Sugawara S, Kuroiwa D, Sekino H, Miyajima M, Kubo H, Oriuchi N, Ito H.”Optimized workflow and imaging protocols for whole-body oncologic PET/MRI.”Jpn J Radiol. 11(116); p1-9;2016
Masuda A, Yamaki T, Sakamoto N, Kunii H, Ito H, Nanbu T, Kubo H, Hara T, Takenoshita S, Takeishi Y.”Vulnerable plaque on the common iliac artery detected by 18F-FDG PET/MRI. ” Eur J Nucl Med Mol Imaging. Apr;43(4):p793-794.;2016
Ishii S, Shimao D, Hara T, Miyajima M, Kikuchi K, Takawa M, Kumamoto K, Ito H, Shishido F.”Comparison of integrated whole-body PET/MR and PET/CT: Is PET/MR alternative to PET/CT in routine clinical oncology?”Ann Nucl Med.;2015
Shimura T, Kofunato Y, Yashima R, Hara T, Ito H, Takenoshita S.”Pilocarpine Hydrochloride Improves Baseline Image of Magnetic Resonance Cholangiopancreatography.”Am J Gastroenterol. ;110(12):ｐ1735-6;2015
Wada K, Niitsuma T, Yamaki T, Masuda A, Ito H, Kubo H, Hara T, Takenoshita S, Takeishi Y.”Simultaneous cardiac imaging to detect inflammation and scar tissue with 18F-fluorodeoxyglucose PET/MRI in cardiac sarcoidosis. ” J Nucl Cardiol. p 1-3;2015
Sakashita T, Hamada N, Kawaguchi I, Hara T, Kobayashi Y, Saito K.　”A branching process model for the analysis of abortive colony size distributions in carbon ion-irradiated normal human fibroblasts” Journal of Radiation Research 55(3);p423－431,2014
Sakashita T, Hamada N, Kawaguchi I, Ouchi NB, Hara T, Kobayashi Y, Saito K. ” A framework for analysis of abortive colony size distributions using a model of branching processes in irradiated normal human fibroblasts.” PLOS ONE　 8(7);p1－11,2013
Zou Y, Cheng C, Omura-Minamisawa M, Kang Y, Hara T, Guan X, Inoue T. ” The Suppression of Hypoxia-inducible Factor and Vascular Endothelial Growth Factor by siRNA Does not Affect the RadiationSensitivity of Multicellular Tumor Spheroids” Journal of Radiation Research 51(1);p47－55,2010
Cheng C, Omura-Minamisawa M, Kang Y, Hara T, Koike I, Inoue T. ”Quantification of circulating cell-free DNA in the plasma of cancer patients during radiation therapy”Cancer Science 100(2);p303－309,2009
Minamimoto R, Hamabe Y, Miyaoka T, Hara T, Yoshida K, Oka T, Inoue T. ” Accelerator mass spectrometry analysis of background ¹⁴C-concentrations in human blood: aiming at reference data for further microdosing studies.”Annals of Nuclear Medicine 22(10);ｐ883－889,2008
Hamada N, Kataoka K, Sora S, Hara T, Omura-Minamisawa M, Funayama T, Sakashita T, Nakano T, Kobayashi Y. ” The small-molecule Bcl-2 inhibitor HA14-1 sensitizes cervical cancer cells, but not normal fibroblasts, to heavy-ion radiation.” Radiotherapy and Oncology 89(2);ｐ227－230,2008
Hara T, Omura-Minamisawa M, Kang Y, Cheng C, Inoue T. ” Flavopiridol potentiates the cytotoxic effects of radiation in radioresistant tumor cells in which p53 is mutated or Bcl-2 is overexpressed.” International Journal of Radiation Oncology*Biology*Physics 71(5);ｐ1485－1495,2008
Hamada N, Hara T（equal contribution）, Omura-Minamisawa M, Funayama T, Sakashita T, Sora S, Nakano T, Kobayashi Y. ”The survival of heavy ion-irradiated Bcl-2 overexpressing radioresistant tumor cells and their progeny.” Cancer Letters 268(1);ｐ76－81,2008
Hamada N, Hara T（equal contribution）, Omura-Minamisawa M, Funayama T, Sakashita T, Sora S, Yokota Y, Nakano T, Kobayashi Y. ” Energetic heavy ions overcome tumor radioresistance caused by overexpression of Bcl-2.” Radiotherapy and Oncology 89(2):p231-236,2008
Hamada N, Hara T, Omura-Minamisawa M, Ni M, Funayama T, Sakashita T, Sora S, Nakano T, Kobayashi Y.　” Heavy-Ion Microbeam Irradiation Induces Bystander Killing of Human Cells” Biological Sciences in Space 22(2);ｐ46－53,2008
Sora S, Hamada N, Hara T, Funayama T, Sakashita T, Yokota Y, Nakano T, Kobayashi Y.　”Exposure of normal human fibroblasts to heavy-ion radiation promotes their morphological differentiation” Biological Sciences in Space 22(2);ｐ54－58,2008
Hamada N, Hara T（equal contribution）, Funayama T, Sakashita T, Kobayashi Y. ”Energetic heavy ions accelerate differentiation in the descendants of irradiated normal human diploid fibroblasts.” Mutation Research 637(1-2);ｐ190－196,2008
Kakizaki T, Hamada N, Sakashita T, Wada S, Hara T, Funayama T, Hohdatsu T, Natsuhori M, Sano T, Kobayashi Y, Ito N. ” Vulnerability of feline T-lymphocytes to charged particles.” The Journal of Veterinary Medical Science 69(6);ｐ605－609,2007
Hamada N, Matsumoto H, Hara T, Kobayashi Y. ” Intercellular and intracellular signaling pathways mediating ionizing radiation-induced bystander effects. ” Journal of Radiation Research 48(2);ｐ87－95,2007
Hara T, Omura-Minamisawa M, Chao C, Nakagami Y, Ito M, Inoue T. ” Bcl-2 inhibitors potentiate the cytotoxic effects of radiation in Bcl-2 overexpressing radioresistant tumor cells.” International Journal of Radiation Oncology*Biology*Physics 61(2);ｐ517－528,2005
Hara T, Ishii T, Fujishiro M, Masuda M, Ito T, Nakajima J, Inoue T, Matsuse T. ”Glutathione S-Transferase P1 has Protective Effects on Cell Viability against Camptothecin.” Cancer Letters 203(2);ｐ199－207,2004
.Nakagami Y, Ito M, Hara T, Inoue T, Matsubara S. ”Nuclear Translocation of DNaseⅡ and Acid Phosphatase during　Radiation-Induced Apoptosis in HL60 Cells．”Acta Oncologica 42(3);ｐ227－36,2003
Nakagami Y, Ito M, Hara T, Inoue T. ” Loss of TRF2 by Radiation-induced Apoptosis in HL60 Cells” Radiation Medicine 20(3);ｐ121－129,2002

［原著，和文］

伊藤浩、石井士朗、久保均、原孝光、島雄大介、南部武幸、富永英之、宍戸文男、竹之下誠一 ” PET/MRIによる癌診断 ” PET journal 29:p31-33 ; 2015
石井士朗, 宍戸文男, 原孝光,島雄　大介, 南部武幸, 久保均, 伊藤浩, 石井信行 “PET/MRIの有用性” 臨床泌尿器科　68(13)：p1034-1039;2014
浜田信行、坂下哲哉、原孝光、藤通有希,　”ヒト正常細胞のコロニー形成実験から明らかになった新事実”放射線生物研究 49(3)：p318-331，2014
石井士朗、原孝光、島雄大介、南部武幸他, ” PET/MRI一体型装置の初期経験臨床利用での有用性と問題点” 臨床放射線 59(8): p1094-1101 2014
石井士朗、宮嶋正之、佐久間光太郎、宍戸文男、原孝光、軟部武幸、島雄大介、久保均, ”PET/MRI　当院での使用状況” 福島県核医学研究会誌 28(1): p13-14 2014
原孝光、島雄大介、大西貴弘、南部武幸、石井士朗、宍戸文男、竹之下誠一,　”ハイブリッドPET/MRIシステムにおける減弱補正マップの検証：減弱補正用MR画像の信号雑音比に対する依存性” 福島県核医学研究会誌 28(1):p8-13, 2014
浜田信行、原孝光、片岡啓子 ”Bcl-2は重粒子線治療の標的となるか ”，放射線生物研究　44(2)：p216-225，2009
宮崎茂、原孝光、松谷一雄、斎藤一彦、　”インバータ式X線装置の短時間特性” 日本放射線技術学会誌　:50(4);ｐ497－504,1994